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PHA-665752

CAT: 0013-GTR19161923-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161923-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHA-665752 is a potent, selective, ATP-competitive c-Met inhibitor with Ki/IC50 of 4/9 nM, inhibits c-Met RTK autophosphorylation in A549 cells with IC50 of 45 nM; exhibits >50-fold selectivity for c-Met against a panel of kinases with exceptions of Ron and VEGFR2 (IC50=68 and 200 nM) ; inhibited HGF-stimulated or constitutive phosphorylation of mediators of downstream signal transduction of c-Met, including Gab-1, ERK, Akt, STAT3, PLCγ, and FAK in multiple tumor cell lines; inhibits c-Met phosphorylation and tumor growth in vivo.
CAS Number
477575-56-7
Product Name Alternative
PHA 665752 | PHA665752
Field of Research
Metabolism Research
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C (C=C (S (=O) (CC3=C (Cl) C=CC=C3Cl) =O) C=C2) /C1=C/C4=C (C) C (C (N5[C@@H] (CN6CCCC6) CCC5) =O) =C (C) N4
Molecular Formula
C32H34Cl2N4O4S
Molecular Weight
641.6078
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Indol-2-one, 5-[[ (2,6-dichlorophenyl) methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[ (2R) -2- (1-pyrrolidinylmethyl) -1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-, (3Z) -

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A2307-5.1PHA-665752
abx076781-01PHA 665752

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