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PHA-680632

CAT: 0013-GTR19171940-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171940-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHA-680632 is a potent, pan-Aurora kinase inhibitor with IC50 values of 27 nM (Aurora A), 135 nM (Aurora B), and 120 nM (Aurora C) . It demonstrates high selectivity, showing 10- to 200-fold less potency against kinases such as FGFR1 and VEGFR2/3. This inhibitor is a valuable chemical probe for studying mitotic progression and cell cycle dysregulation in both cellular and animal cancer models.
CAS Number
398493-79-3
Product Name Alternative
AuroraKinase, Aurora Kinase, Aurora C, Aurora A, Aurora B, Inhibitor, FGFR1, inhibit, PHA 680632, PHA680632, PHA-680632, PLK1
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction
Purity
98.20% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.58 mM) ; DMSO:93 mg/mL (185.4 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CCc1cccc (CC) c1NC (=O) N1Cc2[nH]nc (NC (=O) c3ccc (cc3) N3CCN (C) CC3) c2C1
Molecular Formula
C28H35N7O2
Molecular Weight
501.62
Storage Conditions
-20°C
Notes
For research use only.

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