Products for Research Use Only
RegisterLogin

AKN-028

CAT: 0013-GTR19170736-03Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19170736-03Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AKN-028 is a potent and orally bioavailable small molecule inhibitor of FLT3 tyrosine kinase, demonstrating an IC50 of 6 nM. It effectively suppresses FLT3 autophosphorylation in a dose-dependent manner and is utilized in preclinical research for investigating acute myeloid leukemia (AML) in both cellular and animal models.
CAS Number
1175017-90-9
Product Name Alternative
Fms like tyrosine kinase 3, FLT3 autophosphorylation, FLT3, inhibit, Inhibitor, CD135, Cluster of differentiation antigen 135, cytotoxic, Apoptosis, AML cell lines, Caspase, AKN 028, AKN028, AKN-028, acute myeloid leukemia
Field of Research
Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction
Purity
97.30% (May vary between batches)
Solubility
DMSO:20 mg/mL (66.15 mM)
Smiles
N (C=1N=C (C=NC1N) C=2C=CN=CC2) C=3C=C4C (=CC3) NC=C4
Molecular Formula
C17H14N6
Molecular Weight
302.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Akn-028

AKN-028 has been used in trials studying the treatment of Acute Myeloid Leukemia.

CAS Number1175017-90-9
PubChem CID44177328
IUPAC Name3-N-(1H-indol-5-yl)-5-pyridin-4-ylpyrazine-2,3-diamine
Molecular FormulaC17H14N6
Molecular Weight302.33
XLogP2
Topological Polar Surface Area92.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity385
SMILES
C1=CC2=C(C=CN2)C=C1NC3=NC(=CN=C3N)C4=CC=NC=C4
InChI
InChI=1S/C17H14N6/c18-16-17(22-13-1-2-14-12(9-13)5-8-20-14)23-15(10-21-16)11-3-6-19-7-4-11/h1-10,20H,(H2,18,21)(H,22,23)
InChIKey
JLRIJKVMMZEKDF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Akn-028
CAS: 1175017-90-9
CID: 44177328
Formula: C17H14N6
MW: 302.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight302.33
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass302.12799447
Monoisotopic Mass302.12799447
Topological Polar Surface Area92.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity385
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19217385-01PTC-028
GTR19174254-01PTC-028
GTR19204775-01SMP-028
GTR19188562-01GLP-1R modulator L7-028
GTR18697414-01MORAb-028 Human Monoclonal Antibody
GTR18210312Mouse CD46, clone EBS-CD-028 (Monoclonal) Antibody
GTR19263621-01G721-0282
GTR19184509-01BI-0282
GTR19257849-01OSUAB-0284
GTR19175193-01AZD-0284

Alternative Products

CatalogName
BUP11584-01AKN-028
MBS5779434AKN-028 trifluoroacetate
T61358AKN-028 acetate
HY-118304AAKN-028 (TFA)
HY-118304B-01AKN-028 (acetate)
BA2872-25PTC-028
HY-P991585MORAb-028
HY-12933BIIB-028
HY-117091DDD-028
MBS3845252-01SMP-028

Popular Products