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G721-0282

CAT: 0013-GTR19263621-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263621-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G721-0282 is an orally active inhibitor of CHI3L1 that reduces the expression of inflammatory proteins and cytokines. It suppresses the activation of the NF-κB signaling pathway, inhibits neuroinflammation, and decreases anxiety-related behaviors. Additionally, G721-0282 significantly curtails the proliferation of osteosarcoma (OS) cells by inhibiting the STAT3 signaling pathway and induces apoptosis in OS cells by upregulating pro-apoptotic protein levels while downregulating anti-apoptotic protein levels. This compound is useful in the study of neuroinflammatory diseases and cancer.
CAS Number
946378-12-7
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C1C2=C (SCC (=O) NCC=C) C (=CN=C2N (C (=O) N1C) C) CCCC
Molecular Formula
C18H24N4O3S
Molecular Weight
376.47
Storage Conditions
-20°C
Notes
For research use only.

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