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AKN-028 acetate

CAT: 0931-T61358Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0931-T61358Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Others, Caspase, Apoptosis, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Proteases/Proteasome, Others, Apoptosis, Angiogenesis
Bioactivity
AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation and induces a dose-dependent cytotoxic response (mean IC50 = 1 μM) . AKN-028 acetate also induces apoptosis by activation of caspase 3 and can be used in acute myeloid leukemia (AML) research [1].
Molecular Formula
C19H18N6O2
Molecular Weight
362.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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