KRN5

CAT: 0804-HY-112126-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112126-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC50 of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis[1].
CAS Number
[1800465-47-7]
UNSPSC
12352005
Target
Nuclear Factor of activated T Cells (NFAT)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/KRN5.html
Purity
98.76
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
COC1=C(OC)C2=C(C=C1)C(CC3=CC=CC=C3F)=C4N(C2=O)CCC(C4=C5)=CC6=C5OCO6
Molecular Formula
C27H22FNO5
Molecular Weight
459.47
References & Citations
[1]Han EJ, et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. EBioMedicine. 2017 Apr;18:261-273.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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