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KRN-633

CAT: 0804-HY-12060-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12060-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRN-633 is a potent VEGFR inhibitor with IC50s of 170, 160 and 125 nM for VEGFR1, VEGFR2 and VEGFR3, respectively.
CAS Number
286370-15-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KRN-633.html
Purity
99.45
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=CC(OC2=NC=NC3=CC(OC)=C(C=C32)OC)=CC=C1NC(NCCC)=O
Molecular Formula
C20H21ClN4O4
Molecular Weight
416.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Nakamura K, et al. KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. Mol Cancer Ther. 2004 Dec;3 (12) :1639-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

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