KRN2 (bromide)

CAT: 0804-HY-112125A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112125A-01Size:5 mg
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Description
KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM.
CAS Number
[1390654-28-0]
UNSPSC
12352005
Target
Nuclear Factor of activated T Cells (NFAT)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/KRN2_bromide.html
Purity
98.81
Solubility
DMSO : 18.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C(CC6=CC=CC=C6F)=C2C=C1.[Br-]
Molecular Formula
C27H23BrFNO4
Molecular Weight
524.38
References & Citations
[1]Han EJ, et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. EBioMedicine. 2017 Apr;18:261-273.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Biomolecules. 2024 Nov 13;14 (11) :1444.|J Immunol. 2021 Jun 1;206 (11) :2652-2667.|J Immunol. 2021 Jun 1;206 (11) :2652-2667.|Johns Hopkins University. 2025.

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