Products for Research Use Only
RegisterLogin

DORA-22

CAT: 0013-GTR19169675-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19169675-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DORA-22 is a dual orexin receptor antagonist used in research to study stress-related sleep disturbances. It has been shown to improve mild stress-induced insomnia in animal models while exhibiting minimal impact on memory, making it a valuable tool for neuropharmacology and sleep disorder research.
CAS Number
1088991-95-0
Product Name Alternative
OXReceptor, OX Receptor, DORA22, DORA-22, DORA 22
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
97.67% (May vary between batches)
Solubility
DMSO:10 mg/mL (23.56 mM)
Smiles
C (=O) (C1=C (C=CC (F) =C1) C=2N=CC=CN2) N3C[C@H] (COC4=CC=C (F) C=N4) CC[C@H]3C
Molecular Formula
C23H22F2N4O2
Molecular Weight
424.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Dora-22

an orexin receptor antagonist; structure in first source

CAS Number1088991-95-0
PubChem CID25126515
IUPAC Name[(2R,5R)-5-[(5-fluoro-2-pyridinyl)oxymethyl]-2-methylpiperidin-1-yl]-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone
Molecular FormulaC23H22F2N4O2
Molecular Weight424.4
XLogP3.6
Topological Polar Surface Area68.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity592
SMILES
C[C@@H]1CC[C@H](CN1C(=O)C2=C(C=CC(=C2)F)C3=NC=CC=N3)COC4=NC=C(C=C4)F
InChI
InChI=1S/C23H22F2N4O2/c1-15-3-4-16(14-31-21-8-6-18(25)12-28-21)13-29(15)23(30)20-11-17(24)5-7-19(20)22-26-9-2-10-27-22/h2,5-12,15-16H,3-4,13-14H2,1H3/t15-,16-/m1/s1
InChIKey
ADNQCBKNFSDDHY-HZPDHXFCSA-N
Chemical Structure
2D Structure
2D structure of Dora-22
CAS: 1088991-95-0
CID: 25126515
Formula: C23H22F2N4O2
MW: 424.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight424.4
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass424.17108228
Monoisotopic Mass424.17108228
Topological Polar Surface Area68.2 Ų
Heavy Atom Count31
Formal Charge0
Complexity592
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19200344-01DORA 42
GTR18887047-01Human DORA protein
GTR19277022-0122-Methoxy-22-oxodocosanoic acid
GTR19022878-01Recombinant Mouse Interleukin-22/IL-22
GTR19023232-01Recombinant Human Interleukin-22/IL-22
GTR1802724022 Antibody
GTR19241428-01DHFR-IN-22
GTR19240180-01BB-22
GTR19235542-01CSF1R-IN-22
GTR19221410-01EGFR-IN-22

Alternative Products

CatalogName
T5500-01DORA-22
HY-113555DORA 42
MBS642072-01IGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA)
MBS7609031-01Recombinant Human DORA
128359-PEIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (PE)
128359-BiotinIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (Biotin)
128359-APCIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (APC)
128358-HRPIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (HRP)
128359-FITCIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (FITC)
MBS6137132-01IGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) APC

Popular Products