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Thalidomide-5-OH

CAT: 0013-GTR19165636-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19165636-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-5-OH is a cereblon (CRBN) -binding ligand derived from thalidomide, used to construct PROTAC molecules for targeted protein degradation. This small molecule enables the study of CRBN-recruiting PROTACs in both cellular and in vivo models for probing disease-related protein functions.
CAS Number
64567-60-8
Product Name Alternative
CRBN, E3 ligase-recruiting Moiety, 2- (2,6-dioxopiperidin-3-yl) -5-hydroxyisoindoline-1,3-dione, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase, inhibit, Inhibitor, PROTAC, Thalidomide, Thalidomide 5 OH, Thalidomide5OH, Thalidomide-5-OH
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
97.54% (May vary between batches)
Solubility
DMSO:60 mg/mL (218.79 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.29 mM)
Smiles
O=C1N (C (=O) C=2C1=CC (O) =CC2) C3C (=O) NC (=O) CC3
Molecular Formula
C13H10N2O5
Molecular Weight
274.23
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-Hydroxythalidomide

5-Hydroxythalidomide is a member of phthalimides.

CAS Number64567-60-8
PubChem CID5743568
IUPAC Name2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione
Molecular FormulaC13H10N2O5
Molecular Weight274.23
XLogP0
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity503
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)O
InChI
InChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)
InChIKey
LJBQRRQTZUJWRC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-Hydroxythalidomide
CAS: 64567-60-8
CID: 5743568
Formula: C13H10N2O5
MW: 274.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight274.23
XLogP30
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass274.05897142
Monoisotopic Mass274.05897142
Topological Polar Surface Area104 Ų
Heavy Atom Count20
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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