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Oxaprozin

CAT: 0013-GTR19162782-02Size: 1 gDry Ice: NoHazardous: No
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Description
Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. (In Vitro) :Oxaprozin induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by Oxaprozin (50 μM) . Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα.Oxaprozin (100 μM) induces the strongest proapoptotic effect and significantly increases CD40L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40L-induced Akt and NF-κB (p65) phosphorylation.
CAS Number
21256-18-8
Product Name Alternative
Daypro | NSC 310839 | Wy 21743
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 27 mg/mL (92.04 mM) ; DMSO: 59 mg/mL (201.14 mM)
Smiles
CC1COC2=C3N1C=C (C (O) =O) C (C3=CC (F) =C2N4CCN (C) CC4) =O
Molecular Formula
C18H15NO3
Molecular Weight
293.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
9-fluoro-3-methyl-10- (4-methylpiperazin-1-yl) -7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Chemical Information

Oxaprozin

Oxaprozin is a monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug and an analgesic. It is a monocarboxylic acid and a member of 1,3-oxazoles. It is functionally related to a propionic acid.

CAS Number21256-18-8
PubChem CID4614
IUPAC Name3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
Molecular FormulaC18H15NO3
Molecular Weight293.3
XLogP4.2
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count22
Formal Charge0
Complexity361
SMILES
C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3
InChI
InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
InChIKey
OFPXSFXSNFPTHF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Oxaprozin
CAS: 21256-18-8
CID: 4614
Formula: C18H15NO3
MW: 293.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight293.3
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass293.10519334
Monoisotopic Mass293.10519334
Topological Polar Surface Area63.3 Ų
Heavy Atom Count22
Formal Charge0
Complexity361
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
018865Oxaprozin
HY-B0808S1-01Oxaprozin-d5

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