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Oxaprozin potassium

CAT: 0931-T60979-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T60979-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
174064-08-5
Target
IκB/IKK, Apoptosis, NF-κB, Akt, COX, Others
Related Pathways
NF-κB, Cytoskeletal Signaling, Apoptosis, Immunology/Inflammation, Neuroscience, PI3K/Akt/mTOR signaling, Others
Bioactivity
Oxaprozin potassium is an orally active and potent inhibitor of COX, with IC50 values of 2.2 μM for human platelet COX-1 and 36 μM for IL-1-stimulated human synovial cell COX-2. It induces cell apoptosis and inhibits NF-κB activation. The inhibition of the Akt/IKK/NF-κB pathway by oxaprozin potassium contributes to its anti-inflammatory properties [1] [2].
Smiles
[K+].[O-]C(=O)CCc1nc(c(o1)-c1ccccc1)-c1ccccc1
Molecular Formula
C18H14KNO3
Molecular Weight
331.412
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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