Oxaprozin potassium

• Target :

  I?B/IKK|||Apoptosis|||NF-?B|||Akt|||COX|||Others

• Related Pathways :

  NF-?B|||Cytoskeletal Signaling|||Apoptosis|||Immunology/Inflammation|||Neuroscience|||PI3K/Akt/mTOR signaling|||Others

• Bioactivity :

  Oxaprozin potassium is an orally active and potent inhibitor of COX, with IC50 values of 2.2 ?M for human platelet COX-1 and 36 ?M for IL-1-stimulated human synovial cell COX-2. It induces cell apoptosis and inhibits NF-?B activation. The inhibition of the Akt/IKK/NF-?B pathway by oxaprozin potassium contributes to its anti-inflammatory properties [1] [2].

• Smiles :

  [K+].[O-]C(=O)CCc1nc(c(o1)-c1ccccc1)-c1ccccc1

• Molecular Formula :

  C18H14KNO3

• Molecular Weight :

  331.412

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  174064-08-5