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PD-184352

CAT: 0013-GTR19162781-02Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162781-02Size:1 g
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Description
A potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5; reduces pMAPK levels in multiple tumor cells, prevents cell cycle progression and induces G1 block; suppresses growth of colon tumors in vivo.Colon Cancer Phase 2 Discontinued (In Vitro) :CI-1040 directly inhibits MEK1 with an IC50 of 17 nM. It has also been shown to have little activity against a panel of related kinases with IC50 values more than 2.5 orders of magnitude higher. Treatment of whole cells with CI-1040 completely inhibits the mitogen-stimulated phosphorylation of ERK. CI-1040 at a concentration of 1 μM is found to inhibit phosphorylation of ERK1 and ERK2 by 99% and 92%, respectively in MDA-MB-231 breast cancer cells. CI-1040 induces apoptosis and inhibits proliferation in U-937 cells in a dose and time-dependent manner. CI-1040 induces a significant increase in PUMA mRNA and protein levels. (In Vivo) :The systemic administration of the MEK inhibitor CI-1040 reduces adenoma formation to a third and significantly restores lung structure. The proliferation rate of lung cells of mice treated with CL-1040 is decreased without any obvious effects on differentiation of pneumocytes.
CAS Number
212631-79-3
Product Name Alternative
CI-1040
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 150 mg/mL
Smiles
O=C (NOCC1CC1) C2=CC=C (F) C (F) =C2NC3=CC=C (I) C=C3Cl
Molecular Formula
C17H14ClF2IN2O2
Molecular Weight
478.6595
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 2-[ (2-chloro-4-iodophenyl) amino]-N- (cyclopropylmethoxy) -3,4-difluoro-

Chemical Information

Ci-1040

2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide is an aminobenzoic acid.

CAS Number212631-79-3
PubChem CID6918454
IUPAC Name2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Molecular FormulaC17H14ClF2IN2O2
Molecular Weight478.7
XLogP5.6
Topological Polar Surface Area50.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count25
Formal Charge0
Complexity472
SMILES
C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
InChI
InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChIKey
GFMMXOIFOQCCGU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ci-1040
CAS: 212631-79-3
CID: 6918454
Formula: C17H14ClF2IN2O2
MW: 478.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight478.7
XLogP35.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass477.97566
Monoisotopic Mass477.97566
Topological Polar Surface Area50.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity472
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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