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Anavex 2-73

CAT: 0013-GTR19160414-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160414-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM) . (In Vivo) :The pre-administration of Blarcamesine leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested.
CAS Number
195615-84-0
Product Name Alternative
AE-37 hydrochloride
Purity
>98% (HPLC)
Solubility
DMSO : 37.5 mg/mL 117.98 mM
Smiles
CN (C) CC1CCOC1 (C2=CC=CC=C2) C3=CC=CC=C3.Cl
Molecular Formula
C19H24ClNO
Molecular Weight
317.85
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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