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VEGFR-2-IN-73

CAT: 0804-HY-178004Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178004Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGFR-2-IN-73 is a potent and selective VEGFR-2 inhibitor, showing selectively inhibition of VEGFR-2 (IC50 = 0.0787 μM) over EGFR (IC50 = 1.31 μM) . VEGFR-2-IN-73 demonstrates potent antiproliferative activity across multiple cancer cell lines. VEGFR-2-IN-73 induces G2/M and Pre-G1 phase arrest and significantly enhances apoptosis. VEGFR-2-IN-73 can be used in cancer research, such as colorectal carcinoma, hepatocellular carcinoma, and breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; VEGFR
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C/C(C1=CC=C(C=C1)S(=O)(N2CCC(CC2)C)=O)=N/N=C3SC(C(C4=CC=CC=C4)=O)=NN\3C5=CC=CC=C5
Molecular Formula
C29H29N5O3S2
Molecular Weight
559.70
References & Citations
[1]Al-Ziyadi SH, et al. Novel Sulfonamide Derivatives as Anticancer Agents, VEGFR‑2 Inhibitors, and Apoptosis Triggers: Design, Synthesis, and Computational Studies. ACS Omega. 2025 Aug 25;10 (35) :39772-39790.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

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