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Lycorine

CAT: 0013-GTR19159218-03Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159218-03Size:1 g
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Description
Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. It is a natural alkaloid extracted from the Amaryllidaceae plant family.
CAS Number
476-28-8
Product Name Alternative
Lycorine | Galanthidine | NSC-401360 | NSC401360
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 25 mg/mL (87.01 mM)
Smiles
C1CN2Cc3cc4c (cc3[C@H]3[C@H]2C1=C[C@@H] ([C@H]3O) O) OCO4
Molecular Formula
C16H17NO4
Molecular Weight
287.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1S,2S,3a1S,12bS) -2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol

Chemical Information

Lycorine

Lycorine is an indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity. It has a role as an anticoronaviral agent, an antimalarial, a protein synthesis inhibitor and a plant metabolite. It derives from a hydride of a galanthan.

CAS Number476-28-8
PubChem CID72378
IUPAC Name(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol
Molecular FormulaC16H17NO4
Molecular Weight287.31
XLogP0
Topological Polar Surface Area62.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Heavy Atom Count21
Formal Charge0
Complexity481
SMILES
C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4
InChI
InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1
InChIKey
XGVJWXAYKUHDOO-DANNLKNASA-N
Chemical Structure
2D Structure
2D structure of Lycorine
CAS: 476-28-8
CID: 72378
Formula: C16H17NO4
MW: 287.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.31
XLogP30
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass287.11575802
Monoisotopic Mass287.11575802
Topological Polar Surface Area62.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity481
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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