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R18 (TFA)

CAT: 0804-HY-P1039A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1039A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].
Product Name Alternative
PHCVPRDLSWLDLEANMCLP (TFA)
UNSPSC
12352209
Target
Raf
Type
Peptides
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r18-tfa.html
Purity
99.91
Solubility
H2O : ≥ 25 mg/mL
Smiles
OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC(C)C)NC([C@H](CS)NC([C@H](CCSC)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CS)NC([C@@H](NC([C@@H]3CCCN3)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C103H158F3N27O31S3
Molecular Weight
2423.73
References & Citations
[1]B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38 (38) :12499-504.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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