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R18

CAT: 0804-HY-P1039Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1039Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R18 is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].
CAS Number
211364-78-2
Product Name Alternative
PHCVPRDLSWLDLEANMCLP
UNSPSC
12352209
Target
Raf
Type
Peptides
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r18.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CS)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CS)C(N[C@@H](CC(C)C)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]6NCCC6
Molecular Formula
C101H157N27O29S3
Molecular Weight
2309.69
References & Citations
[1]B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38 (38) :12499-504.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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