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7α,25-Dihydroxycholesterol

CAT: 0804-HY-113962-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113962-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183) . 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM) . 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].
CAS Number
64907-22-8
Product Name Alternative
7α,25-OHC
UNSPSC
12352211
Target
EBI2/GPR183; Endogenous Metabolite
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/7-alpha-25-dihydroxycholesterol.html
Purity
99.88
Solubility
DMSO : 4.55 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=C[C@H]3O)C)([H])CC1
Molecular Formula
C27H46O3
Molecular Weight
418.65
References & Citations
[1]Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475 (7357) :519-23.|[2]Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475 (7357) :524-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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