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7α,27-Dihydroxycholesterol

CAT: 0804-HY-W414548Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W414548Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC) ; it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2) . Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC) .
CAS Number
4725-24-0
UNSPSC
12352211
Target
EBI2/GPR183; Endogenous Metabolite
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/7α-27-dihydroxycholesterol.html
Purity
99.00
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)CO)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@H]3O)C
Molecular Formula
C27H46O3
Molecular Weight
418.65
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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