7ß,27-Dihydroxycholesterol

CAT: 0804-HY-138115Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-138115Size:1 mg
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Description
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM) . 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].
CAS Number
[240129-43-5]
Product Name Alternative
7β, 27-OHC
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/7-27-dihydroxycholesterol.html
Purity
99.5
Solubility
10 mM in DMSO|Ethanol : ≥ 20mg/mL
Smiles
C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C27H46O3
Molecular Weight
418.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Soroosh P, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc Natl Acad Sci U S A. 2014 Aug 19;111 (33) :12163-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ

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