IRAK1/4/pan-FLT3 Kinase-IN-1

IRAK1/4/pan-FLT3 Kinase-IN-1

• CAS Number: 2760328-82-1
• UNSPSC Description: IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, with an IC50 of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. IRAK1/4/pan-FLT3 Kinase-IN-1 has good pharmacokinetic properties and shows promising potential for research in acute myeloid leukemia, with a survival prolongation effect comparable to that of Gilteritinib (HY-12432)[1].
• Target Antigen: FLT3; IRAK
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Protein Tyrosine Kinase/RTK
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/irak1-4-pan-flt3-kinase-in-1.html
• Smiles: CC(O)(C1=CN2C(C=C1OC)=NC=C2C3=NC(N[C@H]4CNCC[C@@H]4F)=CC=C3)C
• Molecular Weight: 399.46
• References & Citations: [1]Hoyt SB, et al. Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia. ACS Med Chem Lett. 2024 Oct 23;15(11):1843-1851.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported