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IRAK1-IN-1

CAT: 0804-HY-158434Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158434Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC50 values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS -induced acute lung injury (ALI) and DSS (HY-116282C) -induced colitis in mice[1].
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irak1-in-1.html
Smiles
CC(N1CCN(CC1)CCOC2=CC(OC3=CC=CC=C23)=O)=O
Molecular Formula
C17H20N2O4
Molecular Weight
316.35
References & Citations
[1]Li X, et al. Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis. Eur J Med Chem. 2024;272:116487.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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