DOR agonist 2

• UNSPSC Description:

  DOR agonist 2 (Compound 3) is a Delta Opioid Receptor agonist. DOR agonist 2 can inhibit the expression of TNF-α, prevent NF-κB transport to the nucleus, and activate the G protein-mediated ERK1/2 pathway. DOR agonist 2 can be used in the study of neurodegenerative diseases[1].

• Target Antigen:

  ERK; NF-κB; Opioid Receptor; TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein;MAPK/ERK Pathway;Neuronal Signaling;NF-κB;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dor-agonist-2.html

• Smiles:

  [H][C@]12C(N(C[C@](C2)([H])CN(C(COC3=CC=CC=C3)=O)C1)C(C=C4)=O)=C4C5=CC6=C(C=C5)C=CC=C6

• Molecular Weight:

  450.53

• References & Citations:

  [1] Damiescu R, et al. Identification of Cytisine Derivatives as Agonists of the Human Delta Opioid Receptor by Supercomputer-Based Virtual Drug Screening and Transcriptomics. ACS Chem Biol. 2024 Aug 21.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1212540-02-7