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DOR agonist 2

CAT: 0804-HY-162850Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162850Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DOR agonist 2 (Compound 3) is a Delta Opioid Receptor agonist. DOR agonist 2 can inhibit the expression of TNF-α, prevent NF-κB transport to the nucleus, and activate the G protein-mediated ERK1/2 pathway. DOR agonist 2 can be used in the study of neurodegenerative diseases[1].
CAS Number
1212540-02-7
UNSPSC
12352005
Target
ERK; NF-κB; Opioid Receptor; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dor-agonist-2.html
Smiles
[H][C@]12C(N(C[C@](C2)([H])CN(C(COC3=CC=CC=C3)=O)C1)C(C=C4)=O)=C4C5=CC6=C(C=C5)C=CC=C6
Molecular Formula
C29H26N2O3
Molecular Weight
450.53
References & Citations
[1] Damiescu R, et al. Identification of Cytisine Derivatives as Agonists of the Human Delta Opioid Receptor by Supercomputer-Based Virtual Drug Screening and Transcriptomics. ACS Chem Biol. 2024 Aug 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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