DOR agonist 2

• Description :

  DOR agonist 2 (Compound 3) is a Delta Opioid Receptor agonist. DOR agonist 2 can inhibit the expression of TNF-α, prevent NF-κB transport to the nucleus, and activate the G protein-mediated ERK1/2 pathway. DOR agonist 2 can be used in the study of neurodegenerative diseases[1].

• UNSPSC :

  12352005

• Target :

  ERK; NF-κB; Opioid Receptor; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dor-agonist-2.html

• Smiles :

  [H][C@]12C(N(C[C@](C2)([H])CN(C(COC3=CC=CC=C3)=O)C1)C(C=C4)=O)=C4C5=CC6=C(C=C5)C=CC=C6

• Molecular Formula :

  C29H26N2O3

• Molecular Weight :

  450.53

• References & Citations :

  [1] Damiescu R, et al. Identification of Cytisine Derivatives as Agonists of the Human Delta Opioid Receptor by Supercomputer-Based Virtual Drug Screening and Transcriptomics. ACS Chem Biol. 2024 Aug 21.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1212540-02-7]