Tauroursodeoxycholate (sodium)

CAT: 0804-HY-19696A-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-19696A-02Size:10 mM - 1 mL

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Description

Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

CAS Number

35807-85-3

Product Name Alternative

Tauroursodeoxycholic acid (sodium) ; TUDCA (sodium) ; UR 906 (sodium)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Caspase; Endogenous Metabolite; ERK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tauroursodeoxycholate-Sodium.html

Concentration

10mM

Purity

98.40

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C26H44NNaO6S

Molecular Weight

521.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92 (2) :307-16.|[2]Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53 (3) :337-345.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Caspase 12; Caspase 3; ERK; Human Endogenous Metabolite

Citation 01

Chemical Information

Taurursodiol sodium

CAS Number	35807-85-3
PubChem CID	46782978
IUPAC Name	sodium 2-[[(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate
Molecular Formula	C26H44NNaO6S
Molecular Weight	521.7
Topological Polar Surface Area	135
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Heavy Atom Count	35
Formal Charge	0
Complexity	864

SMILES

C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+]

InChI

InChI=1S/C26H45NO6S.Na/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29;/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-;/m1./s1

InChIKey

IYPNVUSIMGAJFC-JUWYWQLMSA-M

Chemical Structure

2D Structure

CAS: 35807-85-3

CID: 46782978

Formula: C26H44NNaO6S

MW: 521.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	521.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	521.27870358
Monoisotopic Mass	521.27870358
Topological Polar Surface Area	135 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	864
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-19696AS	Tauroursodeoxycholate-d4 (sodium)
HY-19696-01	Tauroursodeoxycholate
HY-19696B-01	Tauroursodeoxycholate (dihydrate)
HY-19696R-01	Tauroursodeoxycholate (Standard)
HY-19696S-01	Tauroursodeoxycholate-d5
HY-19696S1	Tauroursodeoxycholate-d4
HY-19696S2-01	Tauroursodeoxycholate-d4-1
HY-19696BR-01	Tauroursodeoxycholate (dihydrate) (Standard)
HY-W791754	Paeonolsilate (sodium)
HY-W272811	Camphorsulfonate (sodium)

Alternative Products

Catalog	Name
T6993-01	Tauroursodeoxycholate sodium
B3275-250	Sodium tauroursodeoxycholate
TBW00430	Tauroursodeoxycholate (Sodium)
A15909-25	Sodium Tauroursodeoxycholate 25mg
A15909-500	Sodium Tauroursodeoxycholate 500mg
A15909-50	Sodium Tauroursodeoxycholate 50mg
C13034	Sodium Tauroursodeoxycholate (TUDC)
A15909-200	Sodium Tauroursodeoxycholate 200mg
A15909-100	Sodium Tauroursodeoxycholate 100mg
31102-01	Sodium Tauroursodeoxycholate (TUDCA Sodium) extrapure, 98%

Tauroursodeoxycholate (sodium)

Chemical Information

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