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AM-92016 (hydrochloride)

CAT: 0804-HY-101253-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101253-01Size:5 mg
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Description
AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK) . AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse[1].
CAS Number
133229-11-5
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/am-92016-hydrochloride.html
Concentration
10mM
Purity
99.28
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CS(=O)(NC1=CC=C(OCC(O)CN(CCC2=CC=C(Cl)C(Cl)=C2)C)C=C1)=O.Cl
Molecular Formula
C19H25Cl3N2O4S
Molecular Weight
483.84
References & Citations
[1]ConnorsSP, etal.Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbitventricular cells. Br J Pharmacol. 1992 Aug;106 (4) :958-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

AM 92016 Hydrochloride
CAS Number133229-11-5
PubChem CID45073415
IUPAC NameN-[4-[3-[2-(3,4-dichlorophenyl)ethyl-methylamino]-2-hydroxypropoxy]phenyl]methanesulfonamide;hydrochloride
Molecular FormulaC19H25Cl3N2O4S
Molecular Weight483.8
Topological Polar Surface Area87.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Heavy Atom Count29
Formal Charge0
Complexity553
SMILES
CN(CCC1=CC(=C(C=C1)Cl)Cl)CC(COC2=CC=C(C=C2)NS(=O)(=O)C)O.Cl
InChI
InChI=1S/C19H24Cl2N2O4S.ClH/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26;/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3;1H
InChIKey
TXOARFPCQOBODS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AM 92016 Hydrochloride
CAS: 133229-11-5
CID: 45073415
Formula: C19H25Cl3N2O4S
MW: 483.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight483.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Exact Mass482.060062
Monoisotopic Mass482.060062
Topological Polar Surface Area87.3 Ų
Heavy Atom Count29
Formal Charge0
Complexity553
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B6482-5AM 92016 hydrochloride
B2569-5AM-92016 Hydrochloride
A20472-100AM-92016 hydrochloride 100mg
A20472-5AM-92016 hydrochloride 5mg
A20472-2AM-92016 hydrochloride 2mg
A20472-200AM-92016 hydrochloride 200mg
A20472-25AM-92016 hydrochloride 25mg
A20472-10AM-92016 hydrochloride 10mg
A20472-50AM-92016 hydrochloride 50mg
A20472-10mM-DAM-92016 hydrochloride 10mM * 1mL in DMSO

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