RegisterLogin

AZD4144

CAT: 0804-HY-162877-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-162877-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AZD4144 is an orally active NLRP3 inhibitor (EC50: 0.082 μM) . AZD4144 effectively inhibits the release of IL-1β when NLRP3 is overactivated, exerting an anti-inflammatory effect. AZD4144 has low inhibitory effect on hERG and low cardiotoxicity. AZD4144 has the potential to study diseases and conditions associated with NLRP3 inflammasome activation[1].
CAS Number
[2890191-41-8]
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR) ; Potassium Channel
Type
Reference compound
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/azd4144.html
Purity
99.67
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C(C2=C(C=CC=C3)C3=C(NC[C@H](O)CO)N=N2)C=CC(C(F)(F)F)=C1
Molecular Formula
C18H16F3N3O3
Molecular Weight
379.33
References & Citations
[1]Lars Anders Mikael Johansson, et al. NLRP3 INFLAMMASOME INHIBITORS. WO2023275366. JP. 2023-01-05.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-154959-01AZD4747
HY-171794AZD1134
HY-113938-01AZD4694
HY-12652-01AZD3147
HY-115870-01AZD8154
HY-139516-01AZD4694 Precursor
HY-154959A-01(9R,12aR) -AZD4747

Alternative Products

CatalogName
BUP22253-01AZD4144

Popular Products