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AZD8154

CAT: 0804-HY-115870-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-115870-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD8154 is a selective PI3Kγδ dual inhibitor. AZD8154 can suppress PI3Kγ and PI3Kδ signaling pathway activation. AZD8154 can be used for the researches of inflammation and immunology, such as asthma[1][2].
CAS Number
[2215022-45-8]
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/azd8154.html
Purity
99.88
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CS(=O)(C1=C2C(CN(C2=O)[C@H](C3CC3)C)=CC(C4=C(C)N=C(NC5=CC=CC(N6C(CCC6)=O)=N5)S4)=C1)=O
Molecular Formula
C27H29N5O4S2
Molecular Weight
551.68
References & Citations
[1]Sadiq MW, et al. Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease. Br J Clin Pharmacol. 2022 Jan;88 (1) :260-270.|[2]Pinkerton JW, et al. PI3Kγδ inhibition suppresses key disease features in a rat model of asthma. Respir Res. 2024 Apr 23;25 (1) :175.|[3]Perry MWD, et al. Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma. J Med Chem. 2021 Jun 24;64 (12) :8053-8075.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PI3Kα; PI3Kγ; PI3Kδ

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