AZD4747

CAT: 0804-HY-154959-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-154959-01Size:1 mg
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Description
AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer[1].
CAS Number
[2489226-14-2]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd4747.html
Purity
99.81
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C=CC(N(C[C@@H]1COC2=C3F)CCN1CC2=CC(C#CC)=[C@]3[C@@]4=C(C=CC=C4O)Cl)=O
Molecular Formula
C24H22ClFN2O3
Molecular Weight
440.89
References & Citations
[1]Kettle JG, et al. Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration. J Med Chem. 2023 Jul 13;66 (13) :9147-9160.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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