AZD3147

CAT: 0804-HY-12652-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12652-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K[1].
CAS Number
[1101810-02-9]
UNSPSC
12352005
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd3147.html
Purity
99.93
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1(C2=NC(C3=CC=C(C=C3)NC(NCCO)=S)=NC(N4[C@H](COCC4)C)=C2)CC1)(C5CC5)=O
Molecular Formula
C24H31N5O4S2
Molecular Weight
517.66
References & Citations
[1]Kurt G Pike, et al. Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J Med Chem. 2015 Mar 12;58 (5) :2326-49.|[2]Michaela Kunova Bosakova, et al. Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies. Hum Mol Genet. 2018 Mar 15;27 (6) :1093-1105.|[3]Rebecca Waetzig, et al. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. Int J Med Sci. 2021 Jan 1;18 (1) :137-149.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTORC1; mTORC2

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