(KO Validated) HER2/ErbB2 Polyclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

This is a (KO Validated) HER2/ErbB2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, MLN19, erb-b2 receptor tyrosine kinase 2

2064

P04626

Human

A synthetic peptide of human HER2/ErbB2

Unconjugated

Polyclonal Antibody

WB

Affinity purification

Antibody

1mg/mL

WB 1:500-1:2000

PBS with 0.05% proclin300,50% glycerol, pH7.3.

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

25kDa

Refer to figures

Rabbit