(KO Validated) PTPN1 Polyclonal Antibody

CAT: 0866-RD90364A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD90364A-01Size:60 μL
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Background
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Description
This is a (KO Validated) PTPN1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
PTPN1, PTP1B
Gene ID
5770
Swiss Prot
P18031
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein of human PTPN1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
113kDa
Observed Molecular Weight
89KDa
Host or Source
Rabbit
Isotype
IgG

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