(KO Validated) CDK4 Polyclonal Antibody

• Background:

  The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

• Description:

  This is a (KO Validated) CDK4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  CDK4, CMM3, PSK-J3

• Gene ID:

  1019

• Swiss Prot:

  P11802

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human CDK4

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, IP

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:200, IP 1:50-1:200

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  70kDa/74kDa/82kDa

• Observed Molecular Weight:

  70kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG