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CDK4 Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18335322-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18335322-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression.
Product Name Alternative
Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3; PSKJ3; CDK4; Crk3; CMM 3
UniProt
P11802
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human CDK4
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Affinity-chromatography
Dilution
WB 1:1000~1:2000 ICC/IF 1:50~1:200 IP 1:50
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IP, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · P11802

Cyclin-dependent kinase 4

CDK4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11802
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDK4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.22
Processing
—
Secondary accessions
B2R9A0, B4DNF9, O00576, Q6FG61
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleCell division

Cellular component

CytoplasmMembraneNucleus

Disease

Disease variantDwarfismIntellectual disabilityPrimary microcephaly

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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