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Anti-SNCA | Alpha-synuclein

CAT: 0451-AS08 358Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0451-AS08 358Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy.
CAS Number
9007-83-4
HS Code
38221900
Gene ID
6622
UniProt
P37840
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant, full length, human alpha-synuclein UniProt: P37840, epitope was mapped between amino acid 1-15
Clonality
Polyclonal
Applications
ELISA (ELISA), Immunolocalization (IL), Western blot (WB)
Field of Research
Parkinson's disease
Dilution
1 : 3000 (ELISA), 1-2 µg/ml (IL), 1 : 1000 (WB)
Purity
Serum
Format
Lyophilized
Reconstitution
For reconstitution add 100 µl of sterile water
Molecular Weight
14 kDa
Additionnal Information
Immunolocalization: human tissue was paraffin-embedded and sectioned. De-waxed and rehydrated in an ethanol gradient. Antigens were retrieved in sodium citrate buffer (pH 6) at 95°C for 1 h. The tissue sections were separately incubated for 1 h at RT with primary antibody and antibody binding was visualized with IgG Preoxidase Reagent Kit.This antibody will recognize human SNCA monomers and multimers in Western blot and can be used to detect fibrills in a sandwich ELISA. In ELISA this antibody can be used for detection, combined with AS13 2719 as a capture antibody.
References & Citations
Bargar et al. (2021) Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories. Mol Neurodegener. 2021 Dec 11;16 (1) :82. doi: 10.1186/s13024-021-00491-y. PMID: 34895275; PMCID: PMC8665327.Brännström et al. (2014) . A generic method for design of oligomer-specific antibodies. PLoS One. 2014 Mar 11;9 (3) :e90857. doi: 10.1371/journal.pone.0090857. eCollection 2014.
Storage Conditions
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Prediction Reactivity
Primates, Chimpanzee, Gorilla
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