Anti-ASyM | Mouse anti-human alpha synuclein N-terminal (clone number 4,2)

Anti-ASyM | Mouse anti-human alpha synuclein N-terminal (clone number 4,2)

• Background: Alpha-synucleinis normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy.
• CAS Number: 9007-83-4
• Host: Mouse
• Reactivity: Human
• Not reactive in: No confirmed exceptions from predicted reactivity are currently known
• Immunogen: Synthetic peptide derived from human alpha-synuclein N-terminal Met1-Val15
• Clonality: Monoclonal
• Applications: Dot blot (Dot), ELISA (ELISA), Immunohistochemistry (IHC)
• Dilution: 1-2 µg/mL (Dot), 2-4 µg/mL (ELISA capture), 10 µg/mL (IHC)
• Purity: Immunogen affinity purified serum in PBS pH 7.4.
• Format: Lyophilized
• Reconstitution: For reconstitution add 50 µl of sterile water
• Molecular Weight: 14 kDa
• References & Citations: Tanudjojoet al. (2021) Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons. Nat Commun. 2021 Jun 21;12(1):3817. doi: 10.1038/s41467-021-23682-z. PMID: 34155194; PMCID: PMC8217249.
• Storage Conditions: For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.