Anti-ASyO2 | Mouse anti-human alpha-synuclein | oligomer-specific (clone number 51,24)

Anti-ASyO2 | Mouse anti-human alpha-synuclein | oligomer-specific (clone number 51,24)

• Background: Alpha-synucleinis normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.
• CAS Number: 9007-83-4
• Host: Mouse
• Reactivity: Human
• Not reactive in: No confirmed exceptions from predicted reactivity are currently known
• Immunogen: Synthetic peptide derived from human alpha-synuclein Glu131-Ala140
• Clonality: Monoclonal
• Applications: Dot blot (Dot), ELISA (ELISA), Immunolocalization (IL)
• Dilution: 1-2 µg/mL (Dot), 2-4 µg/mL (ELISA capture), 10 µg/mL (IHC)
• Purity: Immunogen affinity purified serum in PBS pH 7.4.
• Format: Lyophilized
• Reconstitution: For reconstitution add 50 µl of sterile water
• Molecular Weight: 14 kDa
• References & Citations: Giarolaet al. (2024). An α-helical peptide-based plasmonic biosensor for highly specific detection of α-synuclein toxic oligomers. Anal Chim Acta. 2024 May 22:1304:342559. doi: 10.1016/j.aca.2024.342559.Brännströmet al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857.
• Storage Conditions: For short time storage please add sodium azide and srote at +4°C.For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.