(KO Validated) APEX1 Polyclonal Antibody

• Background:

  Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

• Description:

  This is a (KO Validated) APEX1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1

• Gene ID:

  328

• Swiss Prot:

  P27695

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein of human APEX1 (NP_542380.1) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IF

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000 IF 1:50-1:100

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  35 kDa

• Observed Molecular Weight:

  39 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG