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AC-099

CAT: 0804-HY-154829Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-154829Size:1 Each
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Description
AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM) . AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].
CAS Number
849459-88-7
UNSPSC
12352005
Target
Neuropeptide FF Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ac-099.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F
Molecular Formula
C9H8ClF3N4
Molecular Weight
264.63
References & Citations
[1]Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55 (13) :6124-36. |[2]Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52 (21) :6511-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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