AC-099

• Description :

  AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM) . AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].

• UNSPSC :

  12352005

• Target :

  Neuropeptide FF Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ac-099.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F

• Molecular Formula :

  C9H8ClF3N4

• Molecular Weight :

  264.63

• References & Citations :

  [1]Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55 (13) :6124-36. |[2]Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52 (21) :6511-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [849459-88-7]