D-5-Hydroxytryptophan

• UNSPSC Description:

  D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range[1][2][3].

• Target Antigen:

  5-HT Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-5-hydroxytryptophan.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)[C@H](N)CC1=CNC2=C1C=C(O)C=C2

• Molecular Weight:

  220.23

• References & Citations:

  [1]J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16(3):419-22.|[2]Shimomura K, et al. Backward walking induced by L-5-hydroxytryptophan in mice. Jpn J Pharmacol. 1981 Feb;31(1):39-46.|[3]Acton G. Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors. Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):129-32.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  4350-07-6