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D-5-Hydroxytryptophan

CAT: 0804-HY-W007223Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W007223Size:1 Each
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Description
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range[1][2][3].
CAS Number
[4350-07-6]
Product Name Alternative
D-5-HTP; 5-Hydroxy-D-tryptophan
UNSPSC
12352209
Hazard Statement
H301
Target
5-HT Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d-5-hydroxytryptophan.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H](N)CC1=CNC2=C1C=C(O)C=C2
Molecular Formula
C11H12N2O3
Molecular Weight
220.23
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16 (3) :419-22.|[2]Shimomura K, et al. Backward walking induced by L-5-hydroxytryptophan in mice. Jpn J Pharmacol. 1981 Feb;31 (1) :39-46.|[3]Acton G. Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors. Res Commun Chem Pathol Pharmacol. 1988 Apr;60 (1) :129-32.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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