D-5-Hydroxytryptophan

• Description :

  D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range[1][2][3].

• Product Name Alternative :

  D-5-HTP; 5-Hydroxy-D-tryptophan

• UNSPSC :

  12352209

• Hazard Statement :

  H301

• Target :

  5-HT Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/d-5-hydroxytryptophan.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)[C@H](N)CC1=CNC2=C1C=C(O)C=C2

• Molecular Formula :

  C11H12N2O3

• Molecular Weight :

  220.23

• Precautions :

  P264-P270-P330-P405-P501

• References & Citations :

  [1]J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16 (3) :419-22.|[2]Shimomura K, et al. Backward walking induced by L-5-hydroxytryptophan in mice. Jpn J Pharmacol. 1981 Feb;31 (1) :39-46.|[3]Acton G. Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors. Res Commun Chem Pathol Pharmacol. 1988 Apr;60 (1) :129-32.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [4350-07-6]