5-Hydroxytryptophol

• Description:

  5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/3-_2-Hydroxyethyl_-1H-indol-5-ol.html

• Purity:

  99.13

• Solubility:

  DMSO : 116.67 mg/mL (ultrasonic)

• Smiles:

  OC1=CC2=C(NC=C2CCO)C=C1

• Molecular Formula:

  C10H11NO2

• Molecular Weight:

  177.20

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Beck O, et al. 5-hydroxytryptophol as a marker for recent alcohol intake. Addiction. 2003 Dec;98 Suppl 2:63-72.|[2]Eccleston D, et al. The formation of 5-hydroxytryptophol in brain in vitro. Br J Pharmacol Chemother. 1966 Dec;28 (3) :367-77.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [154-02-9]