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Ent-Ezetimibe

CAT: 0804-HY-135388Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135388Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1].
CAS Number
1376614-99-1
Product Name Alternative
Ent-SCH 58235
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ent-ezetimibe.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC=C(F)C=C2)[C@@H](C3=CC=C(O)C=C3)[C@@H]1CC[C@H](C4=CC=C(F)C=C4)O
Molecular Formula
C24H21F2NO3
Molecular Weight
409.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.|[2]Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. An International Journal for Rapid Communication of Synthetic Organic Chemistry
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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