Ent-Ezetimibe

• Description :

  Ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1].

• Product Name Alternative :

  Ent-SCH 58235

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ent-ezetimibe.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C2=CC=C(F)C=C2)[C@@H](C3=CC=C(O)C=C3)[C@@H]1CC[C@H](C4=CC=C(F)C=C4)O

• Molecular Formula :

  C24H21F2NO3

• Molecular Weight :

  409.43

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.|[2]Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. An International Journal for Rapid Communication of Synthetic Organic Chemistry

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1376614-99-1]