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Ezetimibe

CAT: 0804-HY-17376-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17376-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
CAS Number
163222-33-1
Product Name Alternative
SCH 58235
UNSPSC
12352005
Hazard Statement
H302, H319, H372, H410
Target
Autophagy; Keap1-Nrf2
Type
Reference compound
Related Pathways
Autophagy; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Ezetimibe.html
Purity
99.95
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O
Molecular Formula
C24H21F2NO3
Molecular Weight
409.43
Precautions
H302, H319, H372, H410
References & Citations
[1]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.|[2]Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21 (25) :7754-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
275400-01Ezetimibe

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