Ezetimibe

• Description:

  Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

• Product Name Alternative:

  SCH 58235

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H319, H372, H410

• Target:

  Autophagy; Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  Autophagy; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Ezetimibe.html

• Purity:

  99.95

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O

• Molecular Formula:

  C24H21F2NO3

• Molecular Weight:

  409.43

• Precautions:

  H302, H319, H372, H410

• References & Citations:

  [1]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.|[2]Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21 (25) :7754-63.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [163222-33-1]