ITM2B Polyclonal Antibody

• Background :

  Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

• Abbreviation :

  ITM2B

• UniProt :

  Q9Y287

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Fusion protein of human ITM2B

• Target :

  ABRI; ABri/ADan amyloid peptide; BRI 2; BRI; BRI2; BRICD 2B; BRICD2B; BRICHOS domain containing 2B; E25B; E3 16; E3-16; FBD; imBRI2; Immature BRI2; Integral membrane protein 2B; ITM 2B; ITM2B; ITM2B; Protein E25B; RDGCA; Transmembrane protein BRI

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB

• Field of Research :

  Neuroscience

• Purification :

  Antigen affinity purification

• Concentration :

  0.96 mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  30 kDa

• Observed Molecular Weight :

  Refer to figures

• Isotype :

  IgG