Recombinant Human ITM2B Protein (His Tag)

• Background:

  Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) . CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.

• Abbreviation:

  ITM2B

• Synonyms:

  BRI; BRI2; Bri; ITM2B; Immature BRI2; Integral Membrane Protein 2B; Protein E25B; Transmembrane Protein BRI; imBRI2

• UniProt:

  Q9Y287

• Accession Number:

  Q9Y287

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Tyr76-Ser266

• Field of Research:

  Neuroscience

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  23.3 kDa

• Observed Molecular Weight:

  29-33 kDa

• Formulation:

  Supplied as a 0.2 μm filtered solution of 20mM Acetate, 10% Trehalose, 25mM NaCl, 10% Glycerol, 0.05% Tween 80, pH 4.5.

• Species:

  Human