EMP2 Polyclonal Antibody

• Background :

  EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.

• Abbreviation :

  EMP2

• UniProt :

  P54851

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide of human EMP2

• Target :

  EMP 2; EMP-2; EMP2; EMP2; Epithelial membrane protein 2; Protein XMP

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Cancer; Developmental biology; Signal transduction

• Purification :

  Affinity purification

• Concentration :

  0.8 mg/mL

• Dilution :

  IHC 1:50-1:200

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG