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BBC3 Polyclonal Antibody

CAT: 0763-E-AB-15523-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-15523-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Abbreviation
BBC3
UniProt
Q9BXH1
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human BBC3
Target
BBC 3; Bbc3; BBC3; BCL 2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; JFY 1; JFY-1; JFY1; p53 up regulated modulator of apoptosis; p53 up-regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Metabolism; Signal Transduction
Purification
Affinity purification
Concentration
0.9 mg/mL
Dilution
WB 1:200-1:1000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
21kDa
Isotype
IgG

UniProtKB · Q9BXH1

Bcl-2-binding component 3, isoforms 1/2

BBC3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BXH1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BBC3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B9EGI3, O00171, Q96PG9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

Mitochondrion

PTM

Phosphoprotein

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