Ganoderic acid T1

CAT: 0804-HY-N11648Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N11648Size:1 Each
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Description
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity[1].
UNSPSC
12352211
Target
Apoptosis; Caspase
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ganoderic-acid-t1.html
Solubility
10 mM in DMSO
Smiles
C[C@]12C3=CCC4C([C@H](OC(C)=O)CC[C@@]4(C3=CC[C@]1(C)C([C@@H]([C@H](C/C=C(C(O)=O)\C)O)C)C[C@@H]2OC(C)=O)C)(C)C
Molecular Formula
C34H50O7
Molecular Weight
570.76
References & Citations
[1]Liu RM, et al. Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system. Chem Biol Interact. 2015 Oct 5;240:134-44.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9

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