Ganoderic acid T1

• Description :

  Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity[1].

• UNSPSC :

  12352211

• Target :

  Apoptosis; Caspase

• Type :

  Natural Products

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ganoderic-acid-t1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@]12C3=CCC4C([C@H](OC(C)=O)CC[C@@]4(C3=CC[C@]1(C)C([C@@H]([C@H](C/C=C(C(O)=O)\C)O)C)C[C@@H]2OC(C)=O)C)(C)C

• Molecular Formula :

  C34H50O7

• Molecular Weight :

  570.76

• References & Citations :

  [1]Liu RM, et al. Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system. Chem Biol Interact. 2015 Oct 5;240:134-44.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3; Caspase 9