Ganoderic acid A

• Description:

  Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

• UNSPSC:

  12352211

• Target:

  Apoptosis; Autophagy; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Ganoderic-acid-A.html

• Purity:

  99.84

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic) |Ethanol : ≥ 50 mg/mL

• Smiles:

  CC1 (C) C (CC[C@]2 (C) C3=C ([C@@]4 ([C@@H] (O) C[C@@H] ([C@]4 (CC3=O) C) [C@H] (C) CC (C[C@@H] (C) C (O) =O) =O) C) [C@@H] (O) C[C@@]12[H]) =O

• Molecular Formula:

  C30H44O7

• Molecular Weight:

  516.67

• References & Citations:

  [1]Radwan FF et al. Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid. J Cell Biochem. 2015 Jan;116 (1) :102-14.|[2]Yao X et al. Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. Planta Med. 2012 Nov;78 (16) :1740-8.|[3]Gill BS et al. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Mol Biol Rep. 2016 Sep 17.|[4]Shao J et al. [Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35 (5) :619-24.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  81907-62-2