Ganoderic acid A

• Description :

  Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

• UNSPSC :

  12352211

• Target :

  Apoptosis; Autophagy; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Ganoderic-acid-A.html

• Purity :

  99.84

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic) |Ethanol : ≥ 50 mg/mL

• Smiles :

  CC1(C)C(CC[C@]2(C)C3=C([C@@]4([C@@H](O)C[C@@H]([C@]4(CC3=O)C)[C@H](C)CC(C[C@@H](C)C(O)=O)=O)C)[C@@H](O)C[C@@]12[H])=O

• Molecular Formula :

  C30H44O7

• Molecular Weight :

  516.67

• References & Citations :

  [1]Radwan FF et al. Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid. J Cell Biochem. 2015 Jan;116 (1) :102-14.|[2]Yao X et al. Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. Planta Med. 2012 Nov;78 (16) :1740-8.|[3]Gill BS et al. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Mol Biol Rep. 2016 Sep 17.|[4]Shao J et al. [Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35 (5) :619-24.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [81907-62-2]