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EDTA-AM

CAT: 0804-HY-D1746-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1746-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA. Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation[1][2].
CAS Number
162303-59-5
Product Name Alternative
EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents; Mitosis
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/edta-am.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C)OCOC(CN(CCN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=O
Molecular Formula
C22H32N2O16
Molecular Weight
580.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Watkins CS, et.al. Effects on K+ currents in rat cerebellar granule neurones of a membrane-permeable analogue of the calcium chelator BAPTA. Br J Pharmacol. 1996 Aug;118 (7) :1772-8. |[2]Maeshima K, et.al. A Transient Rise in Free Mg2+Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation. Curr Biol. 2018 Feb 5;28 (3) :444-451.e6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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